Motrin administration and precautions

Motrin uses

In children Motrin Suspension is indicated for use in the following health events: fever reduction in children (6 months up to 2 years of age); pain relief in the same category of children; pain relief in children with juvenile arthritis.

In adult patients Motrin is indicated to treat primary dysmenorrhea, rheumatoid arthritis and osteoarthritis.

Motrin – Clinical Pharmacology

Motrin (ibuprofen) is used to decrease the hormones that cause inflammation in the body. It is also indicated to reduce fever and treat headaches, toothache, pack pain, arthritis, menstrual discomforts, etc.

The main component of Mortrin Ibuprofen produces anti-inflammatory and analgesic effects as well as antipyretic activity. It stops the production of prostaglandin.

Ibuprofen in the form of oral suspension formulation is quickly absorbed from the stomach, the peak plasma levels are observed within 1 to 2 hours. It is recommended to use Motrin on an empty stomach. The use of food may slightly delay the absorption of the drug.

Ibuprofen is well distributed in the organs, it is 99% protein bound. In patients with kidney function impairment, the elimination of the drug may be reduced.

Clinical Studies

The clinical trials of Motrin in children in the age from 6 months to 12 years with fever due to various reasons, have demonstrated high effectiveness and safety. The fever reduction normally occurred between 2-3 hours after use. In some patients this period was shorter, in others – longer.

Both ibuprofen doses and acetaminophen were equally effective in children and produced significant relief of fever and pain for as long as 8-10 hours.

The medicine produces the analgesia and inhibition of prostaglandin synthesis which reduces the inflammation.

Along with the necessary effects Motrin can produce some unpleasant health events.

The increased risk of gastrointestinal effects such as ulceration, bleeding, and perforation is common for all NSAIDs, including Motrin medicine.

Serious gastrointestinal side effects such as inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine can be prevented by correct use of the medicine. The duration of use of this medicine increases the risks of upper gastrointestinal effects.

Patients should be in the know that Motrin is used as a short –term treatment.

Effects on kidney function can occur due to long-term administration of Motrin. It can be toxic to the body and impair the kidney function. In patients with serious kidney disease the medicine is not used.

Reactions from the skin related to Motrin use may include exfoliative dermatitis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These skin reactions are very serious and demand immediate medical treatment.

What is Motrin PM (diphenhydramine and ibuprofen)?

Motrin is a combined medicine with two main components: diphenhydramine and ibuprofen.
Diphenhydramine belongs to the drug class of antihistamine medicines which work to decrease the level of natural chemical histamine in the body. Histamine is responsible for increased reactions from the organism and causes watery eyes, sneezing, runny nose, itching.  Antihistamine diphenhydramine relieves these symptoms by inhibiting the actions of histamine.insomnia
Antihistamine diphenhydramine is used to treat insomnia as antihistamines can cause drowsiness and sleepiness.
Ibuprofen is the other component in Motrin. It is a nonsteroidal anti-inflammatory drug (NSAID). This medicine is used alone or with other drugs. Ibuprofen diminishes hormones that are causing inflammation and pain.
Motrin is used to treat insomnia related to mild pain. The medicine should not be used to treat insomnia caused by other reasons.

Motrin with other drugs

iCA760JZ1Ask your health care provider before using an antidepressant.Taking any of the next  drugs with Motrin may cause you to bleed easily or bruise: escitalopram (Lexapro), citalopram (Celexa), sertraline (Zoloft), fluvoxamine (Luvox), fluoxetine (Sarafem,Prozac,  Symbyax), paroxetine (Paxil).

Tell your health care professional, if you use:

• aspirin or other NSAIDs:  naproxen ( Treximet, Naprosyn,Aleve, Naprelan), diclofenac (Cambia,Arthrotec,   Voltaren,Cataflam, Flector Patch, Solareze, Pennsaid), celecoxib (Celebrex), meloxicam (Mobic),indomethacin (Indocin),  and others;

• heart or blood pressure medicine: enalapril (Vasotec), benazepril (Lotensin), lisinopril (Zestril, Prinivil),  ramipril (Altace), quinapril (Accupril) and others;

• lithium (Lithobid, Eskalith);

• diuretics (water pills) : furosemide (Lasix);

• methotrexate (Trexall, Rheumatrex);

• steroids (prednisone);

• a blood thinner such as warfarin (Jantoven,Coumadin).

Before taking

This drug may cause circulation or  life-threatening heart problems: stroke,heart attack and especially if you use Motrin long term.

Motrin may also cause serious effects on the  intestines or stomach, including forming of a hole (perforation) or bleeding .

if youhave allergic reaction  to aspirin, ibuprofen,  or other NSAIDs, you should not use Motrin.

Ask a  pharmacist or doctor about may you use this drug or no, if you have:

  •  high blood pressure;
  •  a history of heart attack;
  •  a history of   blood clot;
  •  a history of  stroke, or
  •  a history of  bleeding
  •  congestive heart failure, heart disease,
  •  a history of stomach ulcers or;
  •  if you smoke.
  •  polyps in your nose;
  •  asthma;
  • kidney or liver disease;
  • SLE (systemic lupus erythematosus);
  • blood clotting disorde
  • a bleeding or r; or


Children’s Motrin: general information

What is Children’s Motrin?

NSAIDs,  has analgesic, antipyretic and anti-inflammatory effect due to non-selective blockade TSOG1 and TSOG2 and have an inhibitory effect the synthesis of Pg. Analgesic effect is most pronounced in inflammatory pain. Like all NSAIDs, ibuprofen exhibits antiplatelet activity.

It is used if you feel pain of mild and moderate intensity when there are cold and flu, sore throat, headache, toothache, fever. Effect lasts 8 hours.

Composition and the form of produce

5 ml suspension for oral administration for children contain ibuprofen 100 mg; in polyethylene bottles with dispenser, 60 and 120 ml;  1 vial complete with measuring cup in the box.


Hypersensitivity, peptic ulcer and duodenal ulcer, asthma, blood disorders, pronounced changes of the function of  liver and kidneys.

Side effects

In rare cases: nausea, vomiting, anorexia, abdominal pain, diarrhea, headache, agitation, insomnia, skin rash, angioedema.

Dosage and administration

Oral, every 6-8 hours, but not more than 4 times a day. Children 2-3 years – 1 tsp suspension, 4-5 years – 1.5 tsp, 6-8 years – 2 tsp, 9-10 years – 2.5 tsp, 11 years – 3 tsp per reception.


Do not take more than 3 days or with drugs which contain ibuprofen and other analgesics or antipyretics (without consulting of a doctor). If you experience stomach upset take with food or milk. With careful use when you have dehydration.

Motrin: drug interaction

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampin, phenylbutazone, and tricyclic antidepressants) enhance the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions.

Inhibitors of microsomal oxidation reduce:

  • the risk of hepatotoxicity;
  • the hypotensive activity of vasodilators (including BCCI and ACE inhibitors), natriuretic and diuretic – furosemide and hydrochlorothiazide;
  • the effectiveness of uricosuric drugs;


  • the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, ulcerogenic action with bleeding ISS and corticosteroids, colchicine, estrogens, ethanol;
  • the effect of oral hypoglycemic drugs or insulin.

Antacids and cholestyramine decrease absorption of ibuprofen. Motrin raises the concentration in blood of digoxin, drugs Li + and methotrexate. Caffeine increases the analgesic effect. With concomitant indication, ibuprofen reduces inflammatory and antiplatelet effect of aspirin (may increase the incidence of acute coronary insufficiency in patients receiving antiplatelet funds as low-dose aspirin, after starting of administration of ibuprofen).

In the appointment of anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase) also it raises the risk of bleeding. Cefamandole, tsefaperazon, tsefotetan, valproic acid, plikamitsin increase the frequency of gipoprotrombinemii. Myelotoxic drugs enhance the expression of  gematotoxicity of the drug.  Cyclosporine and  Au drugs increase the effect of ibuprofen at the synthesis of Pg in the kidney, which is manifested by increased nephrotoxicity.  Ibuprofen raises the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion, reduce excretion and increase plasma concentrations of ibuprofen.

Motrin : contraindications and side effects


Hypersensitivity, erosive and ulcerative diseases of the digestive tract (including gastric ulcer and 12 duodenal ulcer, ulcerative colitis, peptic ulcers, Crohn’s disease), “Aspirin” asthma, coagulation disorders (in including hemophilia, prolongation of bleeding time, bleeding tendency, bleeding diathesis), pregnancy, lactation. Liver cirrhosis with portal hypertension, hyperbilirubinemia, peptic ulcer and 12 duodenal ulcer, gastritis, enteritis, colitis, liver and / or renal failure, nephrotic syndrome, heart failure, hypertension, blood diseases of unknown etiology (leukopenia and anemia ).

Side effects

  • From the digestive system: NSAID-gastropathy (nausea, vomiting, abdominal pain, heartburn, loss of appetite, diarrhea, bloating, pain and discomfort in the epigastric region), ulceration of the mucous membrane of the gastrointestinal tract (in some cases complicated by perforation and hemorrhage), irritation, dryness of the mucous membranes of the mouth, or pain in the mouth, ulceration of the mucous membrane of the gums, mouth disease, pancreatitis, constipation, hepatitis.
  • The respiratory system: dyspnea, bronchospasm.
  • From the senses: hearing loss, ringing or tinnitus, reversible toxic optic neuritis, blurred vision or double vision, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma.
  • Nervous system disorders: headache, dizziness, insomnia, anxiety, nervousness and irritability, agitation, drowsiness, depression, confusion, hallucinations, rarely – aseptic meningitis (usually in patients with autoimmune diseases).
  • From the сardiovascular system: the development or worsening of heart failure, tachycardia, increased blood pressure.
  • Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
  • Allergic reactions: skin rash (usually erythematous, rash), itching, angioedema, anaphylactic reaction, anaphylactic shock, bronchospasm, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome) , eosinophilia, and allergic rhinitis.
  • From the part of the blood: anemia (including hemolytic, aplastic), thrombocytopenia, and thrombocytopenic purpura, agranulocytosis, leukopenia.

Motrin (ibuprofen) : analgesic, antipyretic and anti-inflammatory agent


Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, low back pain, neuralgic amyotrophy (illness of Personeydzha-Turner), arthritis in SLE (as a part of combination therapy), gouty arthritis, ankylosing spondylitis. Pain syndrome: myalgia, arthralgia, ossalgiya, arthritis, sciatica, migraine, headache (including with menstrual syndrome), and toothache, in oncology, neurology, tendonitis, tenosynovitis, bursitis, post-traumatic and postoperative pain, accompanied by inflammation. Tuberculosis, inflammation of the pelvis, including adnexitis, childbirth (as analgesic and tocolytic agent). Feverish syndrome with “cold” and infectious diseases.

Dosage and administration

Oral, after eating.

Adults: in osteoarthritis, psoriatic arthritis and ankylosing spondylitis –  400-600 mg 3-4 times a day. In rheumatoid arthritis – 800 mg three times a day; injuries of soft tissue, sprains – 1.6-2.4 g / day in divided doses. When algodismenoree – 400 mg 3-4 times a day, with moderate pain – 1.2 g / day.

Children over 12 years starting dose – 150-300 mg 3 times a day, the maximum dose – 1 g, then – 100 mg 3 times a day; in juvenile rheumatoid arthritis – 30-40 mg / kg / day in divided doses. To reduce the body temperature 39.2 degrees celsius and above – 10 mg / kg / day, below 39.2 degrees celsius – 5 mg / kg / day. Oral suspension – 5.10 mg / kg, 3 times a day, children aged 6-12 months (prescription-only) – on the  average – 50 mg 3-4 times daily, 1-3 years – 100 mg 3 times a day, 4-6 years – 150 mg 3 times daily, 7-9 years – 200 mg 3 times a day, 10-12 years – 300 mg 3 times a day. With feverish syndrome after immunization – 50 mg.