Motrin administration and precautions

Motrin uses

In children Motrin Suspension is indicated for use in the following health events: fever reduction in children (6 months up to 2 years of age); pain relief in the same category of children; pain relief in children with juvenile arthritis.

In adult patients Motrin is indicated to treat primary dysmenorrhea, rheumatoid arthritis and osteoarthritis.

Motrin – Clinical Pharmacology

Motrin (ibuprofen) is used to decrease the hormones that cause inflammation in the body. It is also indicated to reduce fever and treat headaches, toothache, pack pain, arthritis, menstrual discomforts, etc.

The main component of Mortrin Ibuprofen produces anti-inflammatory and analgesic effects as well as antipyretic activity. It stops the production of prostaglandin.

Ibuprofen in the form of oral suspension formulation is quickly absorbed from the stomach, the peak plasma levels are observed within 1 to 2 hours. It is recommended to use Motrin on an empty stomach. The use of food may slightly delay the absorption of the drug.

Ibuprofen is well distributed in the organs, it is 99% protein bound. In patients with kidney function impairment, the elimination of the drug may be reduced.

Clinical Studies

The clinical trials of Motrin in children in the age from 6 months to 12 years with fever due to various reasons, have demonstrated high effectiveness and safety. The fever reduction normally occurred between 2-3 hours after use. In some patients this period was shorter, in others – longer.

Both ibuprofen doses and acetaminophen were equally effective in children and produced significant relief of fever and pain for as long as 8-10 hours.

The medicine produces the analgesia and inhibition of prostaglandin synthesis which reduces the inflammation.

Along with the necessary effects Motrin can produce some unpleasant health events.

The increased risk of gastrointestinal effects such as ulceration, bleeding, and perforation is common for all NSAIDs, including Motrin medicine.

Serious gastrointestinal side effects such as inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine can be prevented by correct use of the medicine. The duration of use of this medicine increases the risks of upper gastrointestinal effects.

Patients should be in the know that Motrin is used as a short –term treatment.

Effects on kidney function can occur due to long-term administration of Motrin. It can be toxic to the body and impair the kidney function. In patients with serious kidney disease the medicine is not used.

Reactions from the skin related to Motrin use may include exfoliative dermatitis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These skin reactions are very serious and demand immediate medical treatment.

What is Motrin PM (diphenhydramine and ibuprofen)?

Motrin is a combined medicine with two main components: diphenhydramine and ibuprofen.
Diphenhydramine belongs to the drug class of antihistamine medicines which work to decrease the level of natural chemical histamine in the body. Histamine is responsible for increased reactions from the organism and causes watery eyes, sneezing, runny nose, itching.  Antihistamine diphenhydramine relieves these symptoms by inhibiting the actions of histamine.insomnia
Antihistamine diphenhydramine is used to treat insomnia as antihistamines can cause drowsiness and sleepiness.
Ibuprofen is the other component in Motrin. It is a nonsteroidal anti-inflammatory drug (NSAID). This medicine is used alone or with other drugs. Ibuprofen diminishes hormones that are causing inflammation and pain.
Motrin is used to treat insomnia related to mild pain. The medicine should not be used to treat insomnia caused by other reasons.

Motrin with other drugs

iCA760JZ1Ask your health care provider before using an antidepressant.Taking any of the next  drugs with Motrin may cause you to bleed easily or bruise: escitalopram (Lexapro), citalopram (Celexa), sertraline (Zoloft), fluvoxamine (Luvox), fluoxetine (Sarafem,Prozac,  Symbyax), paroxetine (Paxil).

Tell your health care professional, if you use:

• aspirin or other NSAIDs:  naproxen ( Treximet, Naprosyn,Aleve, Naprelan), diclofenac (Cambia,Arthrotec,   Voltaren,Cataflam, Flector Patch, Solareze, Pennsaid), celecoxib (Celebrex), meloxicam (Mobic),indomethacin (Indocin),  and others;

• heart or blood pressure medicine: enalapril (Vasotec), benazepril (Lotensin), lisinopril (Zestril, Prinivil),  ramipril (Altace), quinapril (Accupril) and others;

• lithium (Lithobid, Eskalith);

• diuretics (water pills) : furosemide (Lasix);

• methotrexate (Trexall, Rheumatrex);

• steroids (prednisone);

• a blood thinner such as warfarin (Jantoven,Coumadin).

Before taking

This drug may cause circulation or  life-threatening heart problems: stroke,heart attack and especially if you use Motrin long term.

Motrin may also cause serious effects on the  intestines or stomach, including forming of a hole (perforation) or bleeding .

if youhave allergic reaction  to aspirin, ibuprofen,  or other NSAIDs, you should not use Motrin.

Ask a  pharmacist or doctor about may you use this drug or no, if you have:

  •  high blood pressure;
  •  a history of heart attack;
  •  a history of   blood clot;
  •  a history of  stroke, or
  •  a history of  bleeding
  •  congestive heart failure, heart disease,
  •  a history of stomach ulcers or;
  •  if you smoke.
  •  polyps in your nose;
  •  asthma;
  • kidney or liver disease;
  • SLE (systemic lupus erythematosus);
  • blood clotting disorde
  • a bleeding or r; or


Children’s Motrin: general information

What is Children’s Motrin?

NSAIDs,  has analgesic, antipyretic and anti-inflammatory effect due to non-selective blockade TSOG1 and TSOG2 and have an inhibitory effect the synthesis of Pg. Analgesic effect is most pronounced in inflammatory pain. Like all NSAIDs, ibuprofen exhibits antiplatelet activity.

It is used if you feel pain of mild and moderate intensity when there are cold and flu, sore throat, headache, toothache, fever. Effect lasts 8 hours.

Composition and the form of produce

5 ml suspension for oral administration for children contain ibuprofen 100 mg; in polyethylene bottles with dispenser, 60 and 120 ml;  1 vial complete with measuring cup in the box.


Hypersensitivity, peptic ulcer and duodenal ulcer, asthma, blood disorders, pronounced changes of the function of  liver and kidneys.

Side effects

In rare cases: nausea, vomiting, anorexia, abdominal pain, diarrhea, headache, agitation, insomnia, skin rash, angioedema.

Dosage and administration

Oral, every 6-8 hours, but not more than 4 times a day. Children 2-3 years – 1 tsp suspension, 4-5 years – 1.5 tsp, 6-8 years – 2 tsp, 9-10 years – 2.5 tsp, 11 years – 3 tsp per reception.


Do not take more than 3 days or with drugs which contain ibuprofen and other analgesics or antipyretics (without consulting of a doctor). If you experience stomach upset take with food or milk. With careful use when you have dehydration.