In children Motrin Suspension is indicated for use in the following health events: fever reduction in children (6 months up to 2 years of age); pain relief in the same category of children; pain relief in children with juvenile arthritis.
In adult patients Motrin is indicated to treat primary dysmenorrhea, rheumatoid arthritis and osteoarthritis.
Motrin – Clinical Pharmacology
Motrin (ibuprofen) is used to decrease the hormones that cause inflammation in the body. It is also indicated to reduce fever and treat headaches, toothache, pack pain, arthritis, menstrual discomforts, etc.
The main component of Mortrin Ibuprofen produces anti-inflammatory and analgesic effects as well as antipyretic activity. It stops the production of prostaglandin.
Ibuprofen in the form of oral suspension formulation is quickly absorbed from the stomach, the peak plasma levels are observed within 1 to 2 hours. It is recommended to use Motrin on an empty stomach. The use of food may slightly delay the absorption of the drug.
Ibuprofen is well distributed in the organs, it is 99% protein bound. In patients with kidney function impairment, the elimination of the drug may be reduced.
The clinical trials of Motrin in children in the age from 6 months to 12 years with fever due to various reasons, have demonstrated high effectiveness and safety. The fever reduction normally occurred between 2-3 hours after use. In some patients this period was shorter, in others – longer.
Both ibuprofen doses and acetaminophen were equally effective in children and produced significant relief of fever and pain for as long as 8-10 hours.
The medicine produces the analgesia and inhibition of prostaglandin synthesis which reduces the inflammation.
Along with the necessary effects Motrin can produce some unpleasant health events.
The increased risk of gastrointestinal effects such as ulceration, bleeding, and perforation is common for all NSAIDs, including Motrin medicine.
Serious gastrointestinal side effects such as inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine can be prevented by correct use of the medicine. The duration of use of this medicine increases the risks of upper gastrointestinal effects.
Patients should be in the know that Motrin is used as a short –term treatment.
Effects on kidney function can occur due to long-term administration of Motrin. It can be toxic to the body and impair the kidney function. In patients with serious kidney disease the medicine is not used.
Reactions from the skin related to Motrin use may include exfoliative dermatitis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These skin reactions are very serious and demand immediate medical treatment.